| National Philanthropic Tr | General nonprofit support | $1,591,322,838 |
| Fidelity Investments Charitable Gift Fund | General nonprofit support | $51,869,044 |
| American Online Giving Foundation Inc | General nonprofit support | $42,134,165 |
| Parker Institute For Cancer Immunotherapy | Health | $40,000,000 |
| City Fund | General nonprofit support | $31,500,000 |
| Cornell University | Education | $26,651,118 |
| United States Olympic and Paralympic Foundation | Youth development | $25,000,000 |
| Gradient Learning | Education | $22,000,000 |
| The Skoll Fund | General nonprofit support | $20,017,562 |
| Minerva University | Education | $20,000,000 |
| College Track | Education | $19,678,774 |
| Primary School | Education | $19,100,000 |
| Gs Donor Advised Philanthropy Fund For Wealth Management Inc | General nonprofit support | $17,172,551 |
| The Board of Trustees of the Leland Stanford Junior University | Education | $16,938,472 |
| University of Southern California | Education | $16,052,632 |
| Clinton Health Access Initiative Inc | International development | $13,848,599 |
| Conservation International Foundation | Environment | $13,131,000 |
| Mercy For Animals | Animal welfare | $12,458,500 |
| Lawndale Christian Development Corporation | Community development | $12,000,000 |
| University of California San Francisco | Education | $10,394,670 |
| Teach For All Inc | Education | $10,013,925 |
| Constellation Institute Inc | Sciences | $10,000,000 |
| Sobrato Foundation | General nonprofit support | $10,000,000 |
| Yampa Valley Community Foundation | Other | $10,000,000 |
| Gates Philanthropy Partners | General nonprofit support | $9,976,903 |
| Exygy Inc | Other | $9,750,000 |
| Voter Registration Project | Other | $8,880,000 |
| The Voter Participation Center | Civic participation | $8,810,800 |
| Vital Strategies Inc | Health | $8,231,570 |
| The Task Force For Global Health Inc | Health | $7,938,867 |
| University of California San Francisco Foundation | Health | $7,816,375 |
| Daffy Charitable Fund | General nonprofit support | $7,500,000 |
| Hopewell Fund | General nonprofit support | $7,379,500 |
| Rockefeller Philanthropy Advisors Inc | General nonprofit support | $7,260,450 |
| Spirit Rock Meditation Center | Religion | $7,007,500 |
| Global Impact | General nonprofit support | $6,827,000 |
| Longview Philanthropy USA Inc | General nonprofit support | $6,785,866 |
| Council On Strategic Risks | International development | $6,671,222 |
| Hawaii Community Foundation | General nonprofit support | $6,589,750 |
| Environmental Defense Fund Incorporated | Environment | $6,557,983 |
| Alzheimers Disease and Related Disorders Association Inc | Health | $6,160,430 |
| Partners In Health A Nonprofit Corporation | Health | $6,098,000 |
| Far Ai Inc | Sciences | $6,015,000 |
| Kansas University Endowment Assoc | Education | $6,000,000 |
| Donor Advised Charitable Giving | General nonprofit support | $5,824,989 |
| University of California Berkeley Foundation | Education | $5,359,055 |
| Sobrato Early Academic Language Program | Education | $5,255,000 |
| Amalgamated Charitable Foundation Inc | General nonprofit support | $5,251,800 |
| School of Leadership-afghanistan Inc | Education | $5,200,000 |
| The Clear Fund | General nonprofit support | $5,153,915 |
| American Journalism Project Inc | Arts & culture | $5,129,000 |
| Rethink Priorities | Sciences | $5,118,886 |
| Digital Nest Inc | Youth development | $5,083,500 |
| Greater Washington Educational Telecommunications Association Inc | Arts & culture | $5,001,000 |
| Pahara Institute | Education | $5,000,000 |
| Time For Change Foundation | Housing and transportation | $5,000,000 |
| Tibet Fund | General nonprofit support | $5,000,000 |
| Yale University | Education | $4,666,562 |
| Evidence Action Inc | International development | $4,440,891 |
| Teach For America Inc | Education | $4,375,800 |
| Trustees of Columbia University | Education | $4,320,750 |
| Human Rights Watch Inc | International development | $4,266,600 |
| National Council For Incarcerated and Formerly Incarcerated Women | Public safety | $4,250,000 |
| Mats Research Inc | Sciences | $4,042,029 |
| One Acre Fund | International development | $4,017,000 |
| Hope Enterprise Corporation | Community development | $4,002,000 |
| Liberty Hill Foundation | General nonprofit support | $4,000,000 |
| Rewild | Environment | $4,000,000 |
| President and Fellows of Harvard College | Education | $3,646,375 |
| Regents of the University of California At San Diego | Education | $3,618,543 |
| Imagine Worldwide | Community development | $3,500,000 |
| Bard College | Education | $3,500,000 |
| International First Committee Association | Sciences | $3,483,000 |
| Rockefeller University | Education | $3,475,382 |
| Morgridge Institute For Researchinc | Health | $3,407,387 |
| Center For Technology and Civic Life | Community development | $3,301,800 |
| J David Gladstone Institutes | Health | $3,263,650 |
| Ted Foundation Inc | Community development | $3,250,000 |
| Second Harvest of Silicon Valley | Food security | $3,153,629 |
| Federation of Jewish Communities of the C I S Inc | Education | $3,150,000 |
| Johns Hopkins University | Education | $3,137,877 |
| California Institute of Technology | Education | $3,099,630 |
| Trustees of the University of Pennsylvania | Education | $3,066,117 |
| Human Cell Atlas Inc | Sciences | $3,011,224 |
| Earthjustice | Environment | $3,006,250 |
| Khan Academy Inc | Education | $3,000,000 |
| Mass General Brigham Incorporated | Health | $3,000,000 |
| Womens Foundation of California | General nonprofit support | $3,000,000 |
| Breakthrough Prize In Life Sciences Foundation | Sciences | $3,000,000 |
| Lone Rock Foundation | General nonprofit support | $3,000,000 |
| African Parks Foundation of America | Environment | $3,000,000 |
| Basic Fund Scholarship Foundation | General nonprofit support | $3,000,000 |
| Philanthropic Ventures Foundation | General nonprofit support | $2,926,810 |
| University of Chicago | Education | $2,922,436 |
| United States Fund For Unicef | International development | $2,837,000 |
| American Civil Liberties Union Foundation Inc | Civic participation | $2,820,760 |
| Regents Univ of California | Education | $2,808,251 |
| Make Something Workshop Inc | Arts & culture | $2,806,800 |
| Childrens Hospital Corporation | Health | $2,801,000 |
| The Barack Obama Foundation | Arts & culture | $2,755,000 |