| Silicon Valley Community Foundation | Public, societal benefit | $366,362,375 |
| Fidelity Investments Charitable Gift Fund | Public, societal benefit | $242,538,360 |
| Renaissance Charitable Foundation Inc | Education | $232,159,325 |
| Johns Hopkins University | Human services | $188,179,282 |
| Blue Meridian Partners Inc | Environment, animals | $150,000,000 |
| Climate Imperative Foundation | Culture & arts | $104,600,000 |
| California Academy of Studio Arts I Nc | Public, societal benefit | $83,105,000 |
| New Venture Fund | Public, societal benefit | $82,092,503 |
| Donor Advised Charitable Giving | Education | $72,074,515 |
| The Board of Trustees of the Leland Stanford Junior University | Education | $66,293,027 |
| Xq Institute | Education | $60,248,075 |
| Rockefeller University | Environment, animals | $41,966,876 |
| Jeremy and Hannelore Grantham Environmental Trust | Education | $40,019,087 |
| 50can Inc | Education | $39,325,000 |
| President and Fellows of Harvard College | Education | $38,665,674 |
| Vital Strategies Inc | Education | $33,356,510 |
| Year Up Inc | Human services | $28,559,000 |
| Center For Employment Opportunities Inc | Education | $25,327,000 |
| Ted Foundation Inc | Human services | $25,137,173 |
| Mercy Housing Inc | Human services | $25,001,000 |
| Slough Farm Foundation | Education | $24,736,000 |
| University of Notre Dame Du Lac | Human services | $24,478,115 |
| Chicago Cred Inc | Public, societal benefit | $23,105,130 |
| Impactassets Inc | Human services | $22,856,124 |
| Opportunity At Work Inc | Public, societal benefit | $20,632,333 |
| Rockefeller Philanthropy Advisors Inc | Human services | $19,206,774 |
| Big Table Project Inc | Public, societal benefit | $18,471,300 |
| American Endowment Foundation | Public, societal benefit | $18,130,778 |
| Vanguard Charitable Endowment Program | Public, societal benefit | $17,680,162 |
| Elemental Excelerator Inc | Public, societal benefit | $17,097,400 |
| Gs Donor Advised Philanthropy Fund For Wealth Management Inc | Environment, animals | $16,479,087 |
| Good Food Institute Inc | Education | $16,468,192 |
| Trustees of Columbia University | Education | $16,273,273 |
| University of California Berkeley Foundation | Human services | $16,203,797 |
| Upwardly Global | Education | $15,325,000 |
| America Achieves Inc | Public, societal benefit | $15,188,000 |
| The Community Preservation Corporation | Human services | $15,000,000 |
| Century Housing Corporation | Public, societal benefit | $15,000,000 |
| United Jewish Appeal Federation of Jewish Philanthropies of Ny Inc | Education | $14,833,217 |
| Cornell University | Education | $14,534,315 |
| Yale University | International | $14,204,315 |
| Living Goods | Education | $14,050,000 |
| Trustees of the University of Pennsylvania | Public, societal benefit | $13,283,633 |
| Pidc Community Capital | Education | $12,350,148 |
| Howard University | Education | $12,176,770 |
| Regents of the University of Michigan | Public, societal benefit | $12,055,790 |
| Locus | Public, societal benefit | $12,000,000 |
| Morgan Stanley Global Impact Funding Trust Inc | Public, societal benefit | $11,564,671 |
| The Milken Institute | International | $11,508,700 |
| Nia Tero Foundation | Education | $11,198,180 |
| Williams College | Education | $10,618,300 |
| Advancium Health Network Inc | Education | $10,582,068 |
| Road2hire | Human services | $10,400,000 |
| Neo Philanthropy Inc | Culture & arts | $10,233,500 |
| Metropolitan Opera Association Inc | Human services | $10,085,216 |
| Impact Seven Incorporated | International | $10,000,000 |
| Coalfield Development Corporation | Human services | $10,000,000 |
| Pacers Basketball Corp Foundation Inc | Public, societal benefit | $10,000,000 |
| End Fund Inc | Public, societal benefit | $9,779,005 |
| Justice and Education Fund Inc | Public, societal benefit | $8,880,000 |
| Woods Hole Oceanographic Institution | Public, societal benefit | $8,878,250 |
| Genesys Works | Education | $8,479,667 |
| Massachusetts Institute of Technology | Education | $8,213,396 |
| Asian Americans Advancing Justice Southern California | Public, societal benefit | $8,016,250 |
| Dasra | Public, societal benefit | $8,012,500 |
| Bvm Capacity Building Institute Inc | Public, societal benefit | $8,000,500 |
| Cypress Hills Local Development Corporation Inc | Human services | $8,000,000 |
| Roc USA LLC | Environment, animals | $8,000,000 |
| Womens Community Revitalization Project | Human services | $8,000,000 |
| Social Finance Inc | Human services | $8,000,000 |
| Natural Resources Defense Council Inc | Human services | $7,573,178 |
| Dc Central Kitchen Inc | Public, societal benefit | $7,539,250 |
| Horizon Institute For Public Service | Health | $7,527,232 |
| Mayo Clinic | Environment, animals | $7,503,890 |
| Ocean Conservancy Inc | Public, societal benefit | $7,313,861 |
| Community Foundation of New Jersey | Education | $7,303,028 |
| University of Texas Foundation | Public, societal benefit | $7,283,000 |
| United Nations Foundation Inc | Public, societal benefit | $7,201,517 |
| Foundation For American Freedom | Environment, animals | $7,125,000 |
| Akashinga Inc | Environment, animals | $7,096,396 |
| Global Fishing Watch Inc | Public, societal benefit | $7,091,253 |
| Raymond James Charitable Endowment Fund | Public, societal benefit | $7,084,080 |
| Brooklyn Community Foundation | Public, societal benefit | $7,040,200 |
| North Star Fund Inc | Human services | $7,010,800 |
| Asian Law Caucus | Environment, animals | $7,005,000 |
| Digdeep Right To Water Project | Public, societal benefit | $7,003,950 |
| Community Loan Fund of New Jersey Inc | Health | $7,000,000 |
| Creating Resources For Empowerment and Action Inc | Public, societal benefit | $7,000,000 |
| National Coalition For Asian Pacific American Community Dev | Health | $7,000,000 |
| Arc Research Institute | Public, societal benefit | $7,000,000 |
| City of Hope | Education | $6,993,690 |
| Trustees of Dartmouth College | Education | $6,732,000 |
| The Church of Jesus Christ of Latter-day Saints | Public, societal benefit | $6,729,832 |
| Bank of America Charitable Gift Fund | Culture & arts | $6,682,266 |
| The Barack Obama Foundation | Public, societal benefit | $6,520,017 |
| Chicago Community Foundation | Education | $6,502,127 |
| Kipp New York Inc | Public, societal benefit | $6,292,250 |
| Robin Hood Foundation | Public, societal benefit | $6,272,281 |
| Climateworks Foundation | Education | $6,241,448 |
| Greene School Inc | Education | $6,215,000 |